Perhaps the answer to this is different depending on what you're doing so I thought I'd post it in the general section.
If I stand for a long time or hold a posture for a long time I generally feel fine but eventually dwindle away. At that point if it's been a while since moving I lock up any muscles I've been using in a painful cramp, even if while standing they generally feel quite relaxed. For example I just did San Ti for about 20 mins on one leg and I can hardly move my left arm as its not used to anything like that. It was absolutely fine until the moment I stopped.
I note that when Bruce trained with Wang Shu Jin he fell many times and had to be picked up so I'm thinking it's not all bad.
I first met Bruce in 1992, as a 17 year old, I had all sorts of fantasies about becoming strong and learning to defend myself. Bruce taught me that through hard work and daily practice a world of incredible depth and peace can be found within the art of Ba Gua Zhang that goes far beyond the ability to knock out King Kong.